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  • CAPS Activity in Priming Vesicle Exocytosis Requires CK2

    CAPS phosphoryla tion by CK2 was constitutive but the elevation of Ca2 in syn aptosomes increased CAPS Ser 5 and 6 dephosphorylation which terminates CAPS activity These results identify a func tionally important N terminal phosphorylation site that regu lates CAPS activity in priming

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  • CAPS activity in priming vesicle exocytosis requires CK2

    CAPS Ca 2 dependent activator protein for secretion functions in priming Ca 2 dependent vesicle exocytosis but the regulation of CAPS activity has not been characterized Here we show that phosphorylation by protein kinase CK2 is required for CAPS activity Dephosphorylation eliminated CAPS activity in reconstituting Ca 2 dependent vesicle exocytosis in permeable and intact

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  • The Vesicle Priming Factor CAPS Functions as a Homodimer

    The Vesicle Priming Factor CAPS Functions as a Homodimer via C2 Domain Interactions to Promote Regulated Vesicle Exocytosis